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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NF2
All Species:
33.64
Human Site:
S518
Identified Species:
67.27
UniProt:
P35240
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35240
NP_000259.1
595
69690
S518
D
T
D
M
K
R
L
S
M
E
I
E
K
E
K
Chimpanzee
Pan troglodytes
XP_001136298
595
69538
S518
D
T
D
M
K
R
L
S
M
E
I
E
K
E
K
Rhesus Macaque
Macaca mulatta
XP_001106489
595
69702
S518
D
T
D
M
K
R
L
S
M
E
I
E
K
E
K
Dog
Lupus familis
XP_534729
596
69793
S518
D
T
D
M
K
R
L
S
M
E
I
E
K
E
K
Cat
Felis silvestris
Mouse
Mus musculus
P46662
596
69758
S518
D
T
D
M
K
R
L
S
M
E
I
E
K
E
K
Rat
Rattus norvegicus
Q63648
586
68693
S500
S
F
D
I
I
G
D
S
L
S
F
D
F
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521866
636
73533
S508
D
A
D
L
K
R
L
S
L
E
I
E
R
E
R
Chicken
Gallus gallus
Q9PU45
583
68536
N507
L
S
S
D
G
V
M
N
H
R
S
E
E
E
R
Frog
Xenopus laevis
NP_001086957
585
68810
S508
S
F
S
M
L
N
D
S
L
P
Y
D
F
K
D
Zebra Danio
Brachydanio rerio
NP_001122179
593
69546
S517
D
T
D
M
K
R
L
S
M
E
I
E
K
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24564
635
74474
T559
D
N
E
M
E
Q
I
T
N
E
M
E
R
N
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781142
608
70697
D532
D
V
D
V
E
K
L
D
K
D
I
E
E
N
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.4
99.8
99.5
N.A.
98.3
95.1
N.A.
61.7
44.8
86.8
82.5
N.A.
47.4
N.A.
N.A.
56.5
Protein Similarity:
100
97.6
99.8
99.5
N.A.
99.3
96.6
N.A.
76.5
65.5
92.7
91.2
N.A.
66.3
N.A.
N.A.
75.4
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
66.6
13.3
13.3
100
N.A.
26.6
N.A.
N.A.
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
40
N.A.
93.3
46.6
33.3
100
N.A.
73.3
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
75
0
75
9
0
0
17
9
0
9
0
17
0
0
17
% D
% Glu:
0
0
9
0
17
0
0
0
0
67
0
84
17
67
0
% E
% Phe:
0
17
0
0
0
0
0
0
0
0
9
0
17
0
0
% F
% Gly:
0
0
0
0
9
9
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% H
% Ile:
0
0
0
9
9
0
9
0
0
0
67
0
0
0
0
% I
% Lys:
0
0
0
0
59
9
0
0
9
0
0
0
50
17
50
% K
% Leu:
9
0
0
9
9
0
67
0
25
0
0
0
0
0
0
% L
% Met:
0
0
0
67
0
0
9
0
50
0
9
0
0
0
0
% M
% Asn:
0
9
0
0
0
9
0
9
9
0
0
0
0
17
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
59
0
0
0
9
0
0
17
0
25
% R
% Ser:
17
9
17
0
0
0
0
75
0
9
9
0
0
0
0
% S
% Thr:
0
50
0
0
0
0
0
9
0
0
0
0
0
0
0
% T
% Val:
0
9
0
9
0
9
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _